An idea to think of for handling proteins that bind to other metal ions:

Create a module similar to the one for handling zinc ions, but with more adjustment parameters so that you can make it handle a wide variety of metal ions.

Then, if you need to handle any proteins bound to at least two types of metal ions, just include two or more of these modules in future versions of minirosetta, but instruct them to get their parameters from different files.

That is exactly how it is handled in Rosetta. An input parameter file handles the type of metal ion and the geometries of how it is bound to the protein. Once we show this approach works for zinc-binding proteins, it can easily be expanded to simulate structures of other metal-binding proteins. Happy crunching!

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http://news.yahoo.com/s/ap/20091007/ap_on_re_eu/eu_nobel_chemistry;_ylt=Ag01r3cRaRMf7FMiASMhIfQnncUF;_ylu=X3oDMTJsMXYzZW9kBGFzc2V0A2FwLzIwMDkxMDA3L2V1X25vYmVsX2NoZW1pc3RyeQRjcG9zAzIEcG9zAzIEc2VjA3luX3RvcF9zdG9yaWVzBHNsawMyYW1lcmljYW5zMWk-

http://www.ivanhoe.com/channels/p_channelstory.cfm?storyid=22569

A zinc-binding enzyme, meprin, related to inflammatory bowel disease:

http://www.eurekalert.org/pub_releases/2009-06/pshm-eii060209.php

A reason to resume work on zinc-binding proteins, although not very urgent:

Scientists develop a coating for socks that cures smelly feet

https://www.msn.com/en-us/health/medical/scientists-develop-a-coating-for-socks-that-cures-smelly-feet/ar-BB1ayGaf?ocid=NL_ENUS_A1_20201101_3_2

Patients with CKD, zinc deficiency at ‘high risk’ for infection-related hospitalizations

https://www.healio.com/news/nephrology/20210302/patients-with-ckd-zinc-deficiency-at-high-risk-for-infectionrelated-hospitalizations

Is protein-bound zinc involved?

Scientists reveal the secrets behind ant teeth super strength

https://www.msn.com/en-us/news/technology/scientists-reveal-the-secrets-behind-ant-teeth-super-strength/ar-AAO4JCk?ocid=NL_ENUS_A1_20210905_12_2